These are benzoic acids in which the hydrogen atom at position 3 of the benzene ring is replaced by a methoxy group. Privacy Policy © IARC 2020 - All Rights Reserved. Vanillic acid (4-hydroxy-3-methoxybenzoic acid) is a dihydroxybenzoic acid derivative used as a flavoring agent. Occurrence in nature. Pricing & availability is not currently available. Correspondence to: Mackenzie M. Grieman (mgrieman@uci.edu) The copyright of individual parts of the supplement might differ from the CC BY 4.0 License. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. Need more advice on solubility, usage and handling? Biochim Biophys Acta. Overview Information Vanilla is a plant. All Rights Reserved. Our previous study indicated that. Vanillic acid: Synonyms: 4-Hydroxy-3-methoxybenzoic acid: Structure: MOL SDF PDB SMILES InChI. The bean (fruit) is commonly used to make flavoring, but it is also used to make medicine. The hepatoprotective effects of syringic acid and vanillic acid have been analyzed in CCl 4-induced liver injury in mice. 3053-3059 e-ISSN:2581-6063 (online), ISSN:0972-5210 AN OVERVIEW OF THERAPEUTIC EFFECTS OF VANILLIC ACID Neha Sharma 1,2,3, Nishtha Tiwari 1, Manish Vyas 1, Navneet Khurana 1, Arunachalam Muthuraman 2,4, Puneet Utreja 5,* 1School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India, PIN- 144 411 An examination of Azan-stained liver sections revealed that syringic acid and vanillic acid obviously suppressed collagen accumulation and significantly decreased the hepatic hydroxyproline content, which is the quantitative marker of fibrosis. | Privacy. Jacobson et al. Thus, Vanillic acid exerts protective effects in isoproterenol induced cardiotoxic rats due to its free radical scavenging, antioxidant and anti-inflammatory properties. These data suggest that the administration of syringic acid and vanillic acid could suppress hepatic fibrosis in chronic liver injury. Type in Product Names, Product Numbers, or CAS Numbers to see suggestions. Mutations in COQ6 cause primary CoQ deficiency, a condition responsive to oral CoQ10 supplementation. This study aims to evaluate the protective effects of. [Pubmed: Myocardial infarction affects a large proportion in the world. It is a conjugate acid of a vanillate. Biomarkers of dietary intake of flavonoids and phenolic acids for studying diet–cancer relationship in humans, InChI=1S/C8H8O4/c1-12-7-4-5(8(10)11)2-3-6(7)9/h2-4,9H,1H3,(H,10,11). Questions? People take vanilla to treat intestinal gas and fever. Additionally, both compounds inhibit the activation of cultured hepatic stellate cells. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities. Biol Pharm Bull 1994;17(12):1573-6. Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. Protective effects of vanillic acid on electrocardiogram, lipid peroxidation, antioxidants, proinflammatory markers and histopathology in isoproterenol induced cardiotoxic rats. Vanillic acid is a monohydroxybenzoic acid that is 4-hydroxybenzoic acid substituted by a methoxy group at position 3. Customer Service, [Ayano Itoh, Katsuhiro Isoda, Masuo Kondoh, Masaya Kawase, Akihiro Watari, Masakazu Kobayashi, Makoto Tamesada, Kiyohito Yagi], © 2020  Merck KGaA, Darmstadt, Germany and/or its affiliates. * Packaging according to customer requirements(5mg, 10mg, 20mg and more). 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC, 4-(2-Hydroxy-1-methoxyethyl)-1,2-benzenediol, *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap, 10 mM * 100 uL in DMSO / Inquiry / In-stock. According to end customer requirements, ChemFaces provide solvent format. is commercially available as a nutritional supplement. During the cultivation, phenolic compounds, such as syringic acid and. 106 Following treatment of mice with syringic acid and vanillic acid, Azan-stained liver sections exhibit reduced collagen accumulation and hydroxyproline content. The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. Our products had been exported to the following research institutions and universities, And still growing. 2010;33(6):983-7. Both of these compounds inhibited the activation of cultured hepatic stellate cells, which play a central role in liver fibrogenesis, and maintained hepatocyte viability. Methylglyoxal itself and methylglyoxal-derived AGEs have been commonly implicated in the development of diabetic neuropathy. [Pubmed. Treatment is however still problematic given the poor bioavailability of CoQ10. Akao, T., Kobashi, K., and Aburada, M. Enzymic studies on the animal and intestinal bacterial metabolism of geniposide. Since these compounds have radical scavenging activity, we examined their protective effect on oxidative stress in mice with CCl(4)-induced liver injury. Sigma-Aldrich offers abstracts and full-text articles by [Ayano Itoh, Katsuhiro Isoda, Masuo Kondoh, Masaya Kawase, Akihiro Watari, Masakazu Kobayashi, Makoto Tamesada, Kiyohito Yagi]. TNF-α | ROS | p38MAPK | JNK | PKC | p47(phox) | IL Receptor | Fas | Caspase. Vanillic acid is a flavoring agent which has hepatoprotective, free radical scavenging, antioxidant and anti-inflammatory properties. We examined the hepatoprotective effect of syringic acid and vanillic acid on CCl(4)-induced chronic liver injury in mice. Contact Four weeks of CCl(4) treatment caused a sufficiently excessive deposition of collagen fibrils. Site Use Terms belongs to the class of organic compounds known as m-methoxybenzoic acids and derivatives. Supplement of Burning-derived vanillic acid in an Arctic ice core from Tunu, northeastern Greenland Mackenzie M. Grieman et al. is commercially available as a nutritional supplement. Effect of vanillic acid on COQ6 mutants identified in patients with coenzyme Q10 deficiency. It is a monohydroxybenzoic acid and a methoxybenzoic acid. The mycelia of the edible mushroom Lentinula edodes can be cultured in solid medium containing lignin, and the hot-water extracts (L.E.M.) for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. Side Effects & Safety There is not enough information to know if caffeic acid is safe when taken as a supplement. [Pubmed: Human COQ6 encodes a monooxygenase which is responsible for the C5-hydroxylation of the quinone ring of coenzyme Q (CoQ). The injection of CCl(4) into the peritoneal cavity caused an increase in the serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. [Pubmed: The mycelia of the edible mushroom Lentinula edodes can be cultured in solid medium containing lignin, and the hot-water extracts (L.E.M.) IARC, 150 Cours Albert Thomas, 69372 Lyon CEDEX 08, France - Tel: +33 (0)4 72 73 84 85 - Fax: +33 (0)4 72 73 85 75. Vanillic acid prevents altered ion pumps, ions, inhibits Fas-receptor and caspase mediated apoptosis-signaling pathway and cardiomyocyte death in myocardial infarcted rats. 1 Plant Archives Vol. try to avoid loss or contamination during handling. identified FA, vanillic acid, and caffeic acid in human urine after ingestion of 1 g of FA. ChEBI. A flavoring agent. Biol Pharm Bull. CONCLUSIONS: Our study also showed that pretreatment with Vanillic acid at the dose of 10mg/kg was highly effective than 5mg/kg. The intravenous administration of syringic acid and vanillic acid significantly decreased the levels of the transaminases. It is also an intermediate in the production of vanillin from ferulic acid. It exerts protective effects in isoproterenol induced cardiotoxic rats, has inhibitory effect on methylglyoxal-mediated glycation in apoptotic Neuro-2A cells via inhibition of glycation mechanisms including ROS, p38 and JNK, PKC and p47(phox). Please email to: service@chemfaces.com. We shipped via FedEx, DHL, UPS, EMS and others courier. 20, Supplement 2, 2020 pp. Inhibitory effect of vanillic acid on methylglyoxal-mediated glycation in apoptotic Neuro-2A cells[Pubmed: Methylglyoxal is a reactive dicarbonyl compound generated as an intermediate of glycolysis during the physical glycation in the diabetic condition. 2011 Oct 1;668(1-2):233-40. 2014 Jan;1842(1):1-6. Hepatoprotective effect of syringic acid and vanillic acid on CCl4-induced liver injury. It is an oxidized form of vanillin. Chem Biol Interact. It is considered to be a potent precursor of advanced glycation end products (AGEs) formation. It has a role as a plant metabolite. 2015 May 5;232:68-76. Reproduction of any materials from the site is strictly forbidden without permission. Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to. Recent ChemFaces New Products and Compounds, Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals, Calculate Dilution Ratios(Only for Reference), 1 Building, No. Eur J Pharmacol. During the cultivation, phenolic compounds, such as syringic acid and vanillic acid, were produced by lignin-degrading peroxidase secreted from L. edodes mycelia. Sigma-Aldrich Products are sold exclusively through Sigma-Aldrich, Inc.